Dipyrone

Description

Dipyrone is a mild, nonsteroidal anti-inflammatory drug with a mechanism of action thought to be similar to that of other NSAIDs that inhibit the production of prostaglandins.

Usage

Dipyrone is prescribed for use in foals and adult horses to reduce fevers. It is also prescribed as an analgesic and anti-inflammatory drug. Some veterinarians prescribe dipyrone for mild cases of colic. With the development of more effective NSAID's, dipyrone is not prescribed as frequently as it once was by veterinarians who have replaced it with phenylbutazone and similar drugs.

Dosage and Administration

Side Effects

The most common side effect is injection site reaction that usually responds to hot compresses and NSAIDs.

Prolonged use may cause bone marrow suppression. Horses receiving prolonged courses of dipyrone should be monitored closely.

Precautions

Dipyrone should be avoided or carefully monitored in horses with liver or kidney disease or gastrointestinal problems.

Dipyrone should be given slowly when injected intravenously, since rapid administration may lead to seizures.

Dipyrone should not be used in horses with a history of blood or bone marrow abnormalities.

Dipyrone should be used with caution in older or debilitated animals.

Dipyrone is a prescription drug approved by the FDA for use in horses. U. S. federal law restricts this drug to use by or on the lawful written or oral order of a licensed veterinarian.

Dipyrone would be prohibited in any drug-free competition. It is important to check with the individual regulatory organization.

Interactions

Dipyrone should not be used in conjunction with phenylbutazone or barbiturates. Dipyrone should not be used concurrently with chlorpromazine, due to potentially serious hypothermia.

Overdose

Overdose may lead to convulsions. Overdose or prolonged use may result in anorexia, oral ulcers, depression, decreased plasma protein, increased creatinine, anemia, and leukopenia.