Omeprazole

Description

Omeprazole is used to prevent ulcers in horses and is also FDA approved to treat existing stomach ulcers.  Studies have shown that more than 90% of race horses and more than 60% of performance horses experience gastric ulcers.  The stress brought about through changes in routine, diet, and exercise regimens, along with traveling and competition, may contribute to their development.  Omeprazole suppresses acid production in the horse's stomach by acting as a gastric acid (proton) pump inhibitor.

Usage

Omeprazole is mainly used to prevent ulcers in horses that are subjected to stress or other conditions that make them prone to stomach ulcers.  It is also used to treat cases of existing ulcers.  Omeprazole is sometimes prescribed as a precaution when NSAIDs, corticosteroids, and other drugs known to cause stomach ulcers are administered.  Maximum suppression of acid production occurs three to five days after beginning treatment.

Dosage and Administration

Side Effects

No adverse side effects are listed in manufacturer's information.

Precautions

Omeprazole should be used with caution in horses that have liver disease or decreased liver function.  Dosage may need to be decreased.

Omeprazole is not recommended for use in pregnant or lactating mares.

Omeprazole is FDA approved for use in horses and is a prescription drug restricted to use by or on the lawful written or oral order of a licensed veterinarian.

Omeprazole is commonly used in competition and race horses.  Individual racing commissions may have established permitted detection levels for this drug.  It is important to check with a knowledgeable veterinarian and with the individual regulatory agency in each case.

Interactions

Omeprazole may affect the clearance of anticoagulants, such as warfarin.

Omeprazole has been used with a variety of commonly given equine medications, including vaccines, antibiotics, diuretics, dewormers, tranquilizers, nonsteroidal anti-inflammatories, and corticosteroids without adverse drug interactions.

Overdose

A wide safety margin has been reported in safety trials conducted by the manufacturer.