pen-TAZ-oh-seen - Pronunciation guide
Pentazocine is a synthetic partial opiate agonist available as two separate salts. The hydrochloric salt found in oral dosage forms is a white, crystalline powder that is soluble in water and also in alcohol. The commercial injection is prepared from a pentazocine base with the assistance of lactic acid. Pentazocine exhibits many of the same characteristics as the true opiate agonists. After absorption, the drug is distributed widely into tissues. In horses, it has been shown to be 80% bound to plasma proteins.
In addition to symptomatic relief of pain in horses with colic, pentazocine is used in the amelioration of pain during postoperative recovery from fractures, trauma, and spinal disorders.
Dosage and Administration
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|Intravenous or Intramuscular injection||0.33-1.1 mg/kg||30 mg/ml||Treatment||NA|
Horses may develop transient ataxia and symptoms of central nervous system excitement. Pulse and respiratory rates may become elevated.
Pentazocine should only be used in combination with a sedative, such as xylazine or detomidine.
Pentazocine should not be used in place of appropriate treatment for colic in horses.
Pentazocine should not be used in debilitated horses.
Pentazocine is FDA approved for use in horses and is a prescription drug to be used or prescribed by a licensed veterinarian.
Pentazocine is a prohibited substance in most sanctioned competitions. Check with the individual regulatory group.
When used with pentazocine, other central nervous system depressants/anesthetic agents may cause increased CNS or respiratory depression. Dosage may need to be decreased. Always consult with a veterinarian.
Little information regarding acute overdose with pentazocine is available. For oral ingestion, the gut should be emptied, if indicated and safe to do so. Naloxone may help relieve overdose effects.
Talwin (Pantazocine Lactate Injection)