pros-tuh-GLAN-din - Pronunciation guide
- Lutalyse Sterile Solution
Prostaglandin is naturally produced in the horse's body. Chemically, it is any of a class of unsaturated fatty acids that are involved in the contraction of smooth muscle, the control of inflammation and body temperature, and many other physiological functions in the body. Synthetic prostaglandin is used in several ways to help control reproduction in mares by manipulation of the estrous cycle and in the termination of pregnancy.
Prostaglandin is used in what is often referred to as "short cycling." After ovulation occurs in the mare, if the mare does not become pregnant when bred, the mare's uterus normally produces enough prostaglandin to terminate the corpus luteum and the mare returns to heat. In some cases, use of synthetic prostaglandin is considered necessary to shorten the cycle so the mare returns to heat sooner. Synthetic prostaglandin may also be used to terminate an early pregnancy.
Prostaglandin is also used in the treatment of uterine infections, such as endometritis and pyometra, which are easier to diagnose and treat during estrus.
Dosage and Administration
(click row for calculator)
|Controlling Time of Estrus of Estrous Cycling Mares|
|Intramuscular injection1||.01 mg/lb||5 mg/ml||Single injection||NA|
Side effects are common, but not usually life-threatening and often diminish within an hour. Common side effects are restlessness, cramping, colic-like pain, panting, sweating, high heart rate, diarrhea, urination, and defecation.
Mares that have been given high levels of anabolic steroids and other hormones may not respond to prostaglandin until their bodies are no longer under the effects of these drugs.
Precautions for humans: Pregnant women, asthmatics, and persons with bronchial disease should not handle this product. If skin is accidentally exposed, the area should be washed immediately.
Prostaglandin is for intramuscular injection only and should not be injected intravenously.
Prostaglandin F2 alpha is FDA approved for use with horses and is a prescription drug restricted to use by or on the lawful written or oral order of a licensed veterinarian.
Prostaglandin is not commonly used in competition horses and would be forbidden in drug-free competition. It is important to check with the individual regulatory group.
Prostaglandins may enhance the activity of other drugs that affect the uterus, such as oxytocin.
Symptoms of overdose are the same as side effects, but more severe.
Estromil Prostaglandin Injection