peye-RIL-uh-meen MA-le-ate - Pronunciation guide
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Pyrilamine maleate is an antihistamine drug used in horses to reduce or prevent allergic reactions to histamines.
Pyrilamine is an antihistamine drug used to treat hypersensitivity reactions caused by foreign proteins or allergens in the horse's body. The skin and respiratory tract are the target for most allergic reactions in horses.
Dosage and Administration
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|Oral||0.3 mg/lb||600 mg/ounce||Every 12 hours||NA|
|Intravenous injection||40-60 mg/100lb||20 mg/ml||Repeat in 6 to 12 hours if needed||NA|
Side effects may include nervousness, convulsions, tremors, palpitations, GI disturbances, sedation, muscular weakness, anorexia, lassitude, and lack of coordination.
Pyrilamine maleate is not approved for use in horses intended for food.
Pyrilamine is a prescription drug according to U. S. federal law, available only on the written or oral order of a licensed veterinarian.
Pyrilamine maleate is prohibited or regulated in most sanctioned competitions. It is important to check with the individual regulatory group. .
Increased sedation can occur if pyrilamine maleate is combined with other CNS depressant drugs. It may partially counteract the anticoagulation effects of heparin or warfarin. Pyrilamine may enhance the effects of epinephrine.
Treatment of overdosage is supportive and symptomatic. The manufacturer suggests using "careful titration" of barbituates to treat convulsions, and analeptics, such as caffeine or amphetamines, to treat CNS depression.
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