Description

Ceftiofur is a newer drug in the class of cephalosporin antibiotics that kill bacteria by disrupting construction of the bacterial cell wall. It is effective against many different bacteria, including Streptococcus zooepidemicus and Strep Equi, which cause major respiratory problems.

Usage

Ceftiofur is used primarily for treatment of respiratory diseases, but may also be used whenever a broad-spectrum antibiotic is desired. It is also prescribed in the treatment of Lyme disease and strangles.

Dosage and Administration

Side Effects

Drug side effects are rare at recommended doses. Pain and swelling at the injection site are sometimes noted, but hot compresses and NSAIDs usually relieve any discomfort.

Diarrhea has been reported with ceftiofur use, but appears to be either dose-related or related to certain populations of young horses.

High doses of ceftiofur given during safety studies caused diarrhea, colic, and loss of appetite.

Precautions

Ceftiofur is not for human use and exposure to this drug should be avoided by people who are allergic or sensitive to penicillin and cephalosporins.

Antibiotic-induced diarrhea can be very serious and life-threatening. If diarrhea occurs while a horse is on ceftiofur, the drug should be discontinued immediately and aggressive supportive therapy for diarrhea may be necessary.

Ceftiofur is FDA-approved and U.S. federal law restricts this drug to use by or on lawful written or oral order of a licensed veterinarian.

Ceftiofur is forbidden in drug-free competitions. Check with the individual regulatory organization for rules relating to therapeutic use of this drug.

Interactions

The use of cephalosporins is not recommended with bacteriostatic antibiotics, such as chloramphenicol, which merely prevent or slow bacterial growth, but don't kill the bacteria.

Overdose

High doses or overdoses of ceftiofur during safety studies caused diarrhea, colic, and loss of appetite.