Description

Pergolide, used to treat Parkinson's disease in humans, works by binding with drug receptors that control production of dopamine, which is a chemical neurotransmitter produced by the brain.  

Horses that have clinical signs similar to Cushing's disease in humans have been successfully treated with pergolide since the early 1990's.  The Cushing's-like symptoms are the result of an enlargement or hypertrophy of the horse's pituitary gland.  Pergolide does not cure pituitary pars intermedia dysfunction, but rather helps manage the symptoms, enabling the horse to lead a near-normal life.

Usage

Pergolide is used to treat horses that have pituitary pars intermedia dysfunction, which, essentially, is caused by an enlargement or hypertrophy of the pituitary gland.  This condition is a common problem with older horses and ponies.  Improvement of clinical signs usually occurs after one or two months.

Dosage and Administration

Pergolide
Method	Dosage (click row for calculator)	Concentration	Period	Duration
Oral1	0.002-0.004 mg/kg	1 mg/tablet		NA
Notes: 1Do not crush tablets. Provide the dose in the closest 1/2 tablet amount. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Extra-label use of drugs in treating animals is allowable only by licensed veterinarians within the context of a valid veterinarian-client-patient relationship, and does not include drug use in treating animals by the layman (except under the supervision of a licensed veterinarian). The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your equine appears to feel better, the entire treatment plan should be completed to prevent relapse. This medication may be available in forms and concentrations not noted in the above table. Always check the label and literature provided with the medication about the form and concentration and DO NOT USE the calculator if the information differs. Calculator is for educational purposes only. Follow your veterinarian's instructions regarding use of this, or any medication.

Side Effects

Precautions

It is important to identify and use the lowest possible dose.  Over time, the condition in some horses may become resistant to medication.

Use of this drug may interfere with lactation and pergolide should be used in pregnant or lactating animals only if the benefits outweigh the risks.

Pergolide is now FDA approved for use in horses.  It is a prescription drug and federal law restricts this drug to use by or on the lawful written or oral order of a licensed veterinarian.

Pergolide is regulated or prohibited in most sanctioned competitions.  Consult a veterinarian and the individual regulatory group regarding its use in competition horses.

Interactions

Phenothiazine tranquilizers, such as acepromazine, may interfere with the action of pergolide.

Overdose

Overdose in humans causes gastrointestinal upset and hallucinations.  No literature is available regarding overdose in horses.