Chronic inflammatory small bowel disease has an increased prevalence in sport horses. The disorder is associated with intermittent colic, weight loss, poor performance and anemia. Chronic inflammatory small bowel disease seems to have a predominance in dressage horses, but its exact cause is unknown to date. Researchers of the Free University of Amsterdam and Utrecht University in the Netherlands have now identified gluten sensitivity as a potential cause of equine chronic inflammatory small bowel disease in sport horses.
Grains containing gluten
Researchers have identified gluten sensitivity as a potential cause of equine chronic inflammatory small bowel disease in sport horses.
Gluten is a major compound of the endosperm of various cereals, in particular of wheat, barley and rye. Especially the gliadin fraction of the gluten is associated with Coeliac disease (gluten intolerance) in man.
Some horses fed a gluten-rich ration showed concurrent antibody responses as seen in celiac patients. To test the pathogenic role of gluten, one sport horse with chronic inflammatory bowel disease and antibodies followed a gluten-free ration during 6 months. Both villous morphology and blood antibody titers improved in this horse.
The development of a screening test aimed at identifying gluten-sensitivity in individual horses based on blood samples is currently in progress.
As reported in the Veterinary Quarterly, "In conclusion, the researchers stated, 'To the best of our knowledge, this is the first study assessing gluten-related antibodies in horses and results suggest a potential pathogenic role of gluten in at least some cases of equine ISBD. Clinical importance and impact for human medicine: Given serology and concurrent clinical findings, this study warrants further investigations into the immunologic basis of possible gluten-sensitive enteropathy in horses and analogy with human disease.'"