Newsdate: Friday, May 5, 2023 - 11:00 am
Location: TEMPE, Arizona
Nonstructural Carbohydrates (NSC), Non Fiber Carbohydrates (NFC), Ethanol Soluble Carbohydrates (ESC), Water Soluble Carbohydrates (WSC) - it all really comes down to hydrolyzable carbohydrates for metabolically challenged horses.
Obese horse with typical founder stance of a horse with laminitis
The only carbohydrate fractions that matter are those that increase insulin when considering metabolically challenged horses.
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Hydrolyzable carbohydrates (HC) are defined as those digestible in the small intestine. Some microbial fermentation occurs in the small intestine but much less than in the hind gut, so hydrolyzable carbohydrates will primarily be absorbed intact.
Starch is digested entirely to glucose. Simple monosaccharide sugars like glucose and fructose are absorbed intact. Disaccharide sugars like sucrose (table sugar) and lactose (milk sugar), and the trisaccharide trehalose, are broken down into monosaccharides by enzymes present at the brush border of the small intestinal cells, then absorbed. These are the HC and the only components that increase blood glucose and therefore insulin.
More complex plant sugars like cellobiose and raffinose cannot be digested and pass through to the hind gut where they are fermented to volatile fatty acids. The same fate awaits all fiber fractions, "resistant" starch not accessible to the digestive enzymes and rapidly fermentable carbohydrates like pectin, fructan and beta-glucan.
The volatile fatty acids/fermentation products produced can substitute for glucose in energy pathways (acetate), be used to feed the colonic cells (butyrate), converted back to glucose or glycogen (propionate, lactate) or fat (butyrate, acetate). None of those substances or reactions will increase insulin. In metabolic horses, it is insulin that causes laminitis.
Forage analysis is geared toward ruminants rather than the simple-stomached horse, so the distinction between HC and fermented doesn't mean as much because they both get fermented in the forestomachs of a ruminant. For now, we have the most data on sugars in hydrolyzable carbohydrates estimated colorimetrically by Ethanol Soluble Carbohydrates (ESC). The sum of ESC + starch will give you the best estimate of total HC in a forage sample – not NSC.
Of 264 independently collected, good quality grass hay samples on file, 97% are under 10% ESC + starch, but only 15% are under 10% NSC.
If using NSC as a threshold, then owners may opt for low to poor quality hays in an effort to achieve that threshold. Even if the threshold is elevated to an arbitrary 12%, only 35% of forage in this database would meet that criteria. Using NSC as a measure of safety places unnecessary burden on owners of horses with metabolic disorders.
About ECIR Group Inc.
Started in 1999, the ECIR Group is the largest field-trial database for PPID and EMS in the world and provides the latest research, diagnosis, and treatment information, in addition to dietary recommendations for horses with these conditions. Even universities do not and cannot compile and follow long term as many in-depth case histories of PPID/EMS horses as the ECIR Group. In 2013 the Equine Cushing's and Insulin Resistance Group Inc., an Arizona nonprofit corporation, was approved as a 501(c)3 public charity. Tax deductible contributions and grants support ongoing research, education, and awareness of Equine Cushing's Disease/PPID and EMS.
THE MISSION of the ECIR Group Inc. is to improve the welfare of equines with metabolic disorders via a unique interface between basic research and real-life clinical experience. Prevention of laminitis is the ultimate goal. The ECIR Group serves the scientific community, practicing clinicians, and owners by focusing on investigations most likely to quickly, immediately, and significantly benefit the welfare of the horse.
Article by Eleanor M Kellon, VMD and Kathleen M. Gustafson, PhD
Press release by Nancy Collins