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DOM-per-i-done - Pronunciation guide
Brand Names
Description
Domperidone is used to treat fescue toxicosis. Endophyte-infected fescue grass is found in and around pastures in most of the United States and is especially prevalent in the South. Toxins produced by the fungal endophyte, Neotyphodium coenophialum, that grows in fescue, depress the hormones necessary for normal labor, delivery, and lactation in mares. Domperidone counteracts the effects of the fungal toxins by competitively blocking dopamine receptors.
Mares that develop fescue toxicosis have increased gestation lengths, poor udder development, low or no milk production, and are prone to a high incidence of premature placental separation or retained placentas, difficult deliveries, and large, weak foals with increased foal and mare mortality. Use of domperidone as prescribed during pregnancy and after foaling greatly reduces complications and aids in milk production.
Usage
Domperidone is used in pregnant mares when fescue toxicosis is diagnosed or suspected. Used after foaling, it aids in milk production.
Domperidone may be used for non-fescue related lack of milk production and for low milk production.
Dosage and Administration
| Method | Amount | Dosage | Period | Duration | Note |
|---|---|---|---|---|---|
| Oral | 0.5 | mg/lb | Daily | 10 - 15 days | Prior to foaling date. May continue for 5 - 10 days after foaling if milk production is inadequate. |
| Oral | 0.5 - 1.14 | mg/kg | Every 12 - 24 hours | Consult vet | For fewcue toxicosis |
Dose Form: Multi-dose oral syringe containing 110 mg/domperidone per ml of gel
Side Effects
Some leakage of milk or colostrum prior to foaling has been reported.
Precautions
Domperidone may cause a false-positive reading on the milk calcium test that is used to predict foaling.
It should not be used when stimulation of the gastrointestinal tract might be dangerous, such as in the presence of GI obstruction, perforation, or hemorrhage.
Domperidone is not yet FDA approved. It is a prescription drug and may be purchased by a veterinarian through the manufacturer. It is only available by or on the lawful written or oral order of a licensed veterinarian. Domperidone is not used in competition horses.
Interactions
Antacids and antisecretory drugs should not be given at the same time as domperidone, as they may influence the absorption of other oral drugs.
Overdose
No information pertaining to overdose is found in the literature.
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