hy-DROX-eh-zeen - Pronunciation guide
- Hydroxyzine HCL: Oral Paste
Hydroxyzine hydrochloride is an antihistamine used to treat allergic skin reactions in horses. The drug works by competing with histamine for uptake at the histamine receptors on sensitive cells in the respiratory tract, intestines, blood vessels, and the skin, thereby counteracting the inflammation and itching of allergic reactions.
Hydroxyzine is given to treat hives, itchy or bumpy allergic skin reactions, and inflammation. Antihistamines given orally take 20 to 45 minutes to begin counteracting the release of histamine from damaged cells and the resulting effect it has on the horse's body.
Dosage and Administration
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|Oral||0.5-1 mg/kg||50 mg/tablet||2 to 4 times daily||NA|
|Intramuscular injection||0.5-1 mg/kg||50 mg/ml||2 to 4 times daily||NA|
Sedation is the most common side effect. Fine tremors, whole body tremors, excitement, and seizures are less common.
High doses of antihistamines can cause birth defects in laboratory animals. Hydroxyzine should only be used in pregnant and lactating animals if the benefits outweigh the risks. Animals may react differently to antihistamines and the dose of hydroxyzine should be tailored to the individual horse.
Hydroxyzine is not FDA approved for use in horses, although its use is considered accepted practice. It is a prescription drug and U.S. federal law restricts this drug to use by or on the lawful written or oral order of a licensed veterinarian.
Hydroxyzine is prohibited or regulated in most sanctioned competitions. It is important to consult the individual regulatory group.
Hydroxyzine has an additive effect when combined with other central nervous system depressant drugs, such as tranquilizers.
Overdose may cause increased sedation and increased risk of other side effects.