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fir-o-KOX-ib EH-kwuh-oks OR-uhl PAYST - Pronunciation guide

Brand Names

  • Equioxx Oral Paste
  • Previcox Chewable Tablets


Firocoxib belongs to the coxib class of non-narcotic, non-steroidal, anti-inflammatory drugs. It is a white crystalline compound that is made into a paste to be used in a syringe in the treatment of horses with osteoarthritis.


Firocoxib is a cyclo-oxygenase-inhibiting, non-narcotic, non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activity in horses. Osteoarthritis is a painful condition caused by progressive damage of cartilage and other parts of the joints that leads to decreases in activity and lameness. Although response varies from horse to horse, improvement can be seen in just a few hours in most horses according to the manufacturer.

Dosage and Administration

Prescription medicationFirocoxib
Method Dosage
(click row for calculator)
Concentration Period Duration
Oral 0.1 mg/kg 56.8 mg/syringe Daily 14 days
Intravenous injection 0.09 mg/kg 20 mg/ml Daily 5 days1


  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.
  • 1Transition from injection to oral dosage if sustaining the treatment beyond 5 days. Continue treatment for up to 14 days.
  • Calculator is for educational purposes only. Follow your veterinarian's instructions regarding use of this, or any medication.

Side Effects

The most common side effects associated with firocoxib - Equioxx therapy involve erosions and ulcers of the mucosa and skin on the tongue, lips, and skin of the mouth and face. Gastrointestinal and renal toxicity may occur.


Treatment should be discontinued if signs such as colic, abnormal feces, lethargy, or lack of appetite occur.

Since NSAIDs possess the potential to produce gastrointestinal ulcerations, use with other NSAIDs or corticosteroids should be avoided or closely monitored.

Safety of use in horses less than one year of age, horses used for breeding and pregnant or lactating mares has not been evaluated.

Firocoxib is FDA approved for oral use in horses only. Federal law restricts this drug to use by or on the order of a licenses veterinarian.

Check with the appropriate individual regulatory body regarding use in competition horses.


Firocoxib should not be given with other NSAIDs including aspirin, phenylbutazone, diclofenac, ketoprofen or flunixin or systemic corticosteroids such as prednisone cortisone, dexamethasone or triamcinolone.

Notify your veterinarian regarding any medications or dietary supplements that your horse may be on so a determination can be made if other interactions might occur.


Consult with your veterinarian if your horse receives more than the prescribed amount of firocoxib.


Equioxx  Paste Equioxx Paste

Equioxx InjectionEquioxx Injection




About the Author

EquiMed Staff

EquiMed staff writers team up to provide articles that require periodic updates based on evolving methods of equine healthcare. Compendia articles, core healthcare topics and more are written and updated as a group effort. Our review process includes an important veterinarian review, helping to assure the content is consistent with the latest understanding from a medical professional.