Hyaluronate Sodium

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hi-uh-LUR-on-ate SO-de-um - Pronunciation guide

Brand Names

  • Hyaluronate Sodium Liquid
  • Legend Injectable Solution
  • Legend Multi Dose Injectable Solution
  • NexHA


Rx symbolFDA-approved intravenous and intra-articular therapy available to treat non-infectious synovitis associated with osteoarthritis in horses. Hyaluronate sodium is the glycosaminoglycan present in normal joint fluid. It is produced by a patented biofermentation process that results in such purity that it can be given intravenously for immediate bioavailability.

NexHA, a generic form of Hyaluronate Sodium has now been approved by the FDA is a formulation of purified hyaluronate sodium that can be administered to horses by intravenous or intra-articular injection.


Hyaluronate sodium is used in the healing of degenerative joint disease. One major function is the regulation of normal cell constituents that decrease the impact of exudation, enzyme release, and subsequent degradation of joint integrity. Injected directly into the joint pouch, it enhances the healing of the inflamed synovium by restoring lubrication of the joint fluid. It also exerts an anti-inflammatory action.

NexHA, the generic form of hyaluronate sodium is indicated in the treatment of joint dysfunction of the carpus or fetlock in horses due to non-infectious synovitis associated with equine osteoarthritis. Hyaluronate sodium acts as a replacement for synovial fluid, the naturally occurring lubricant in articular joints.

Dosage and Administration

Prescription medicationHyaluronate Sodium
Method Dosage Concentration Period Duration
IV injection 4 ml 10 mg/ml Weekly

Up to 3 treatments

Intra-Articular injection1 2 ml 10 mg/ml Weekly Up to 3 treatments


  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.
  • Extra-label use of drugs in treating animals is allowable only by licensed veterinarians within the context of a valid veterinarian-client-patient relationship, and does not include drug use in treating animals by the layman (except under the supervision of a licensed veterinarian).
  • 1Stall rest on days following treatment before gradually resuming normal activity.

Side Effects

No local or systemic side effects have been observed in clinical trials with either intravenous or intra-articular injections.


Radiographic evaluation should be used in cases of acute lameness to rule out fractures or other serious conditions.

Precautions should be followed as to injection technique and sterility for prevention of swelling or infection.

Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle.

For intravenous administration, use asceptic technique and inject slowly into the jugular vein.

Horses should be given stall rest after treatment and before gradually resuming normal activity.

Federal law restricts this drug to use by or on the lawful written or oral order of a licensed veterinarian.

Product is not for use in horses intended for human consumption.


None noted.


Check manufacturer's information.


Hyaluronate Sodium Liquid SolutionHyaluronate Sodium Liquid Solution

Legend Hyaluronate Sodium InjectionLegend Hyaluronate Sodium Injection



About the Author

EquiMed Staff

EquiMed staff writers team up to provide articles that require periodic updates based on evolving methods of equine healthcare. Compendia articles, core healthcare topics and more are written and updated as a group effort. Our review process includes an important veterinarian review, helping to assure the content is consistent with the latest understanding from a medical professional.