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pol-ee-GLY-can - Pronunciation guide

Brand Names

  • Polyglycan Injection
  • Tandem


Rx symbolPolyglycan is a patented formulation of hyaluronic acid, sodium chondroitin sulfate, and N-acetyl-D-glucosamine in a highly viscous aqueous solution for use in horses. Glucosaminoglycans are important components of extracellular tissue structures, including cartilage and synovial fluid.

This composition of supplements is very similar to Legend and Adequan, plus Glucosamine. It is not the exact structure, since those products are patented.


Polyglycan Sterile Solution is used for post-surgical lavage of synovial compartments of joints. It is designed to replace synovial fluid lost during surgery and helps maintain the homeostatic environment of the joint. As a lavage prior to surgical closure of the joint space, Polyglycan assists in normalization of the joint.

Anecdotal evidence suggests that Polyglycan, which is similar in composition to Legend and Adequan, may be given intravenously in situations where these two patented products might be used. No scientific studies have been done to assess the effects when administered via the IV or IM routes and this usage would be off-label and would most likely not be covered by any insurance company.

Dosage and Administration

Prescription medicationPolyglycan
Method Dosage Concentration Period Duration
Lavage 10 ml 1 ml/ml 1 Procedure NA


  • 1Each 10 mL vial contains: Hyaluronic acid sodium salt 50.0 mg, Sodium chondroitin sulfate 1000 mg, N-acetyl-D-glucosamine 1000 mg.


  • This product is not a generic version of Adequan.
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.
  • Extra-label use of drugs in treating animals is allowable only by licensed veterinarians within the context of a valid veterinarian-client-patient relationship, and does not include drug use in treating animals by the layman (except under the supervision of a licensed veterinarian).
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your equine appears to feel better, the entire treatment plan should be completed to prevent relapse.
  • This medication may be available in forms and concentrations not noted in the above table. Always check the label and literature provided with the medication about the form and concentration and DO NOT USE the calculator if the information differs.
  • Calculator is for educational purposes only. Follow your veterinarian's instructions regarding use of this, or any medication.

Side Effects

None noted in literature.


Do not administer to animals that are to be used for human consumption.

Store at 60-85 F. Discard any unused portions of vials.

Polyglycan Sterile Solution is FDA-approved for use in horses and is a prescription drug restricted to use by or on the lawful written or oral order of a licensed veterinarian.

Check with the appropriate individual regulatory body regarding use in competition horses.


None noted in literature.


Check manufacturer's information.


Polyglycan InjectionPolyglycan Injection


About the Author

EquiMed Staff

EquiMed staff writers team up to provide articles that require periodic updates based on evolving methods of equine healthcare. Compendia articles, core healthcare topics and more are written and updated as a group effort. Our review process includes an important veterinarian review, helping to assure the content is consistent with the latest understanding from a medical professional.