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treye-peh-LEN-uh-meen - Pronunciation guide

Brand Names

  • Re-Covr Injection
  • TripelenJect Injection
  • Tripelennamine Hydrochloride
  • Triple Histamine


Rx symbolTripelennamine hydrochloride is a white, crystalline material that is stable and readily soluble in water. It is derived from pyridine and ethylemediamine and used in the form of a crystaline citrate as an intramuscular injection.

Tripelennamine competes with histamines for uptake at the histamine receptors on sensitive cells in the respiratory tract, intestines, blood vessels, and skin.

It may be used with corticosteroids, allowing use of a lower dose of corticosteroids in the control of allergic reactions.


Tripelennamine is used in horses for conditions requiring antihistaminic therapy to treat allergic problems, such as hives, and itchy or bumpy skin conditions, and for the alleviation of allergic reactions, such as tongue or facial swelling due to bee stings, insect bites, or contact with irritating plants.

Dosage and Administration

Prescription medicationTripelennamine
Method Dosage
(click row for calculator)
Concentration Period Duration
Intramuscular injection 0.5 mg/lb 20 mg/ml Daily 5 days


  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.
  • Extra-label use of drugs in treating animals is allowable only by licensed veterinarians within the context of a valid veterinarian-client-patient relationship, and does not include drug use in treating animals by the layman (except under the supervision of a licensed veterinarian).
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your equine appears to feel better, the entire treatment plan should be completed to prevent relapse.
  • This medication may be available in forms and concentrations not noted in the above table. Always check the label and literature provided with the medication about the form and concentration and DO NOT USE the calculator if the information differs.
  • Calculator is for educational purposes only. Follow your veterinarian's instructions regarding use of this, or any medication.

Side Effects

Sedation is a common side effect with antihistamine use. Less common side effects include fine tremors, seizures, excitement, and colic or loss of appetite.


Individual horses may react differently to antihistamines. Dosage may need to be tailored to the individual horse.

Tripelennamine may thicken mucus in the horse's respiratory tract. Extra caution should be taken in use with horses with respiratory problems.

Tripelennamine should be given only intramuscularly.

Tripelennamine is FDA-approved for use in horses, and is a prescription drug restricted to use by or on the lawful written or oral order of a licensed veterinarian.

Tripelennamine is prohibited or regulated in most sanctioned competitions. Check with the appropriate regulatory group regarding rules and regulations for use in competition horses.


Tripelennamine may have an additive effect when combined with other central nervous system depressant drugs, such as tranquilizers.

Tripelennamine may affect the activity of anticoagulant drugs, such as warfarin.


Overdose of tripelennamine would be expected to increase sedation and severity of other side effects.


Rally 20 Tripelennamine Injection  Rally 20 Tripelennamine Injection



About the Author

EquiMed Staff

EquiMed staff writers team up to provide articles that require periodic updates based on evolving methods of equine healthcare. Compendia articles, core healthcare topics and more are written and updated as a group effort. Our review process includes an important veterinarian review, helping to assure the content is consistent with the latest understanding from a medical professional.